Have we hit a wall with whole kidney decellularization and recellularization: A review

The purpose of organ decellularization is to remove all cellular components whilst preserving the extracellular matrix (ECM). It has been hypothesized that this decellularized ECM can be used as a scaffold for development personalized bioengineered kidneys by repopulating it with patient-derived cells. renal artery, vein, and ureter are most frequently whole kidney repopulation. Cell perfusion through artery vein enables revascularization kidneys. However, adequate repopulation epithelial compartment remains unattainable. Although become unlikely recellularized will solution reduce donor shortages within foreseeable future, advances made field recellularization have paved way alternatives actually may help solve these shortages. This includes ex vivo refurbishment personalization discarded organs during machine perfusion.